The history of insulin

Hormone secreted by the pancreas, insulin was discovered I is since the beginning of the 1900s shallow historically. This hormone I was found to provide a revolutionary change in diabetes.

Bring about revolutionary changes in diabetes, I am since the beginning of the 1900s. In rare endocrine tissue organs and exocrine glands that secrete digestive juices, called islets of Langerhans that secrete hormones are mixed, the pancreas was still unknown that work for many years. Over time, it can be seen that to become a diabetes by excising the pancreas experimentally, I was discovered to be related to hormone the cause of diabetes is secreted by the pancreas.

It was named the insulin that hormone out of the island, but the extraction of the insulin is extremely difficult, scientists around the world were challenged, but failed all, had been to give up almost one oclock.

However, I was able to young researchers in 1921, two of the best and Banting is, to extract the insulin from the pancreas of dogs was atrophy exocrine glands at last. It has the "World Day of diabetes," the birthday of Banting to commemorate this. (November 14)

After repeated animal studies, insulin extracted, was tried in the patient carefully. The patient was the situation for diabetes patients who developed as a youngster in the (type 1 diabetes), insulin is not secreted at all, that there is no so alms hand, can only wait for death. Insulin is injected for the first time to the child, survival benefit was obtained dramatic. Then, extracted or insulin from the pancreas of pigs and cattle, it is now sufficient in quantitative terms. Porcine insulin was very similar to human insulin Fortunately.
However, for the time you have worked in the body from the injected short, it was must be injected 8 times 6 times a day. In addition, extraction technology is low insulin at the time, there was also that because it is not a pure insulin, antibodies or an allergic reaction, the insulin to? Is produced in the body, effectiveness of insulin is weakened.

Entire amino acid sequence of insulin is known, it has been administered to humans of various improvements have been made now.